Full support has been patched into the kernel for a couple years now, and Focusrite seems to be pretty friendly to Linux compared to other manufacturers.
No noticeable lag or buffering that I've found. I've played around with a few DAWs, but I don't need them for my workflow, so I haven't spent a ton of time with them, and I'm no audio engineer.
The Focusrite control software doesn't work, but you can get remote control capabilities lots of other ways on Linux such as with remote Pulse Audio or Pipewire control, or simply using SSH.