Let's say every human has 100 hit points before they croak. Now let's say you've been hit with a curse where you take 1d6 damage every time you laugh. How many days would you survive?
Hardmode: no healing ever.
Easy mode: you heal 5 hp per long rest.
Folks either way I'm not making it past one one week, hell I'm worried I'll make it through one day if it's a good day to laugh.
Source material