I'd go with a live image of whatever distro you're most familiar with. I usually go with the arch iso or endeavor os if I need a GUI.
You can't set 2 different DPIs for the monitors on X11. On one monitor everything is just going to be bigger than the other. Depending on the DPI difference it can be basically unusable.
I swap between the two. X11 and i3 when I'm using my laptop alone. Wayland and gnome when I'm docked with multiple monitors.
If your monitors are different DPIs then multimonitor X11 is awful.
If you're questioning why anyone would have monitors with different DPIs remember that laptops exist.
I'm not switching on my main laptop until xwayland app scaling is figured out. Either figure out how to make the apps scale properly or just leave them tiny on my screen. None of this stretching them to fit and making them blurry bullshit.
I use it on everything else because all my other computers don't have high dpi screens.
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