Own the Moonlander and my hands aren’t particularly small (men’s size L gloves), and still found the thumb cluster keys too far to be regularly useful. I’m not even sure it’s just about size, but the way your hand naturally moves/stretches (or doesn’t) possibly plays a part, too.
That said, I still love the thing because Oryx is SO good, it was my perfect intro to fully programmable KBs, and allowed me to experiment SO much that I was able to gradually/quickly optimize layouts until I settled (a couple of months without modifying layout), on what now feels like the perfect fit for my needs.
With that knowledge/experience I was now able to move on to a Corne-ish Zen, but I’m keeping the Moonlander as back up, and for experimenting.
Attaching pictures of my latest Moonlander configuration, which I’ve kept for a while now and love.
Here’s my current layout: https://configure.zsa.io/moonlander/layouts/Wgay4/latest/0