https://medicalxpress.com/news/2023-09-dose-psilocybin-safe-effective-treatment.html
A collaboration between 34 researchers at 18 institutions has looked into the efficacy and safety of psilocybin in patients with major depressive disorder.
25mg of psilocybin, not 25mg dried mushrooms. This isn't an insignificant dose, roughly equivalent to 2.5g of dried mushrooms.
Thanks, was hoping to find this in the comments. That's actually much lower than I expected, always thought you had to go on a 5g journey. I personally don't even get visual hallucinations on 2.5g
Oh damn. That’s getting to the point of tripping right? I’ve been microdosing 500mg of dried mushrooms for a little bit now and have felt some mood stabilization from it but this has me wondering if I should go for a heavy dose and see how it goes.
I absolutely recommend a 2g dose, it's just a fun, comfortable, good trip for the majority of people. Some people will trip harder than others, but I've never met anyone who didn't enjoy a 2g trip and if you're already microdosing 500mg without much effect you won't be going off the rails tripping or anything. I'd consider it a starter dose.
Makes sense as long as it works, a lot of people are not prepared to trip balls anyway, even as part of a treatment. Ketamine (for the same purpose, which is increasingly a thing) has the same issue.
Never done drugs but depression is fucking horrible and debilitating. If the price to pay for putting depression on hiatus for a year or two is tripping balls, sign me the fuck up right now. I swear the first second I am retired (and thus can't get fired for drugs) I am investigating one of these types of treatments. But my understanding is micro dosing is generally the treatment? Idk.
Fun fact, a lot of employers don't test for mushrooms. If it's a 5 panel test, they don't test for it at all.
Fun fact, it's legal to purchase spores and grow kits in the US, since they don't contain any psilocybin.
I've thought about trying to grow some, it doesn't look hard, but just like all things that look easy there is likely a lot of underlying info I'd have to find or learn the hard way... and right now I'm trying to keep from being that guy who has a bunch of half-finished projects.
It’s easy. If you’re going to worry about anything it’s the legality of it, the chances of getting caught, and what might happen to you if you were to some how get caught.
Nothing will be worse for your depression than dealing with the legal ramifications of a schedule 1 possession and/or cultivation charge.
Yeah that's the OTHER reason I haven't done it. I make decent money and have a loving family, and I'm not really wanting to burn all that down to grow mushrooms.
It's really extremely easy. You get these premade boxes that you unpack and set into a corner and leave there for a couple of weeks. Some other boxes might need to water them first. It's really easy and a nice experience growing them.
a nice experience growing them.
You see, this is the other reason I want to try. This year my wife and I planted vegetables in our garden, and it was so cool to have all this growing stuff that we could eat.
I agree and have literally done that exact thing for that exact purpose... but not everyone does.
My point was just that having a drug that doesn't require tripping balls in a tightly controlled setting is a good idea. Not everyone is up for it (personality, circumstances) and any trip has risks, you need monitoring which takes trained manpower etc. - it's worth it while we have no other treatment, but it isn't very practical for a bunch of reasons.
Microdosing would be dependent on the chemical.
Unless you live in a state/country where there are clinical trials/treatment options, youre basically left with 3 options. 1. Foraging, psilocybin shrooms are everywhere (unsafe unless you're very confident in your findings) 2. Order online (still unsafe but less chance of accidental poisoning, also runs the risk of law enforcement) or 3. That guy from highschool still probably knows someone that can hook you up.
Mushrooms are 100% legal in Jamaica. They were never illegal (as weed is). So the government actually has special business licenses for people who sell them, to promote tourism.
Huh, interesting. I wonder if there are mushroom retreats/'resorts' (for lack of a better term, what I'm thinking would be pretty small). If it was 100% legal this seems like a no brainer, and a good opportunity for psychedelic therapists to practice (similar, in some ways, to people going to Mexico for medical procedures, but addressing a different access problem).
I'll need to look it up myself - I have a hard time trusting social media posts that say mushrooms are no-strings legal (I see a lot of folks saying this about Canada, which is just straight-up false - if you're part of a clinical trial or your doctor filled out a LOT of paperwork, sure, but despite being open those mushroom dispensaries and clear web services are still 100% illegal). But if true, I'd be curious to see how that's taken advantage of from a business and therapeutic point of view.
Edit: Does appear to be a thing. Wish I had a better source, but this is published on the Jamaica Information Service, which appears to be a government operated thing (look at the sidebar under Corporate for more details): https://jis.gov.jm/protocols-in-place-for-magic-mushrooms/
Yeah, I am going to call bullshit on this one. I tried shrooms once and it seemed like it helped, but then my depression came back a little over a year and a half later.
I mean... if one dose alleviated your depression for a year and a half then it sounds very effective
Why are you expecting it to last forever? It's common for relapse to occur with mental illness.