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What is an interesting concept in science fiction that you feel hasn't been explored?

This includes science fantasy.

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I haven't seen a lot and don't really read (but it's empty here anyway) but

I'd like to see more related to see cyborg stuff, beyond just prosthesis and aesthetics. The type of thing where there isn't much organic left besides the brain and symbiotic systems. Living in different forms.

@Gamers_Mate

Meta notes:

GitS probably has some of this and I should probably watch, but not really the feel I'm hoping for especially with religious/existential themes
Farscape has some of this with the leviathans, but also a string of bad events related (that ship needs therapy)
lovable robots often have the feel down, and while none of the explanation is there it often could work in a headcanon sort-of-way especially when backstory is not explained fully