Define better?
I am not a doctor and you should really talk to yours.
SSRIs stay in your system forever and take a while to build up. Timing a fast drug like THC with that doesn't matter imo, though I bet there is some acutely larger amount in the blood after taking it.
That being said I take my ssri in the morning and take an edible at night if I am going to.
Eh? Zoloft made weed hit harder, but it also made it hit way different. If you want couch lock, I'd say just do THC and CBN. If you want a more sativa-y high, afterwards