!cfs@feddit.de
This is a new place for people coming from r/cfs.
For research, treatments, and personal stories regarding Chronic Fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME). ME/CFS is a multi-systemic neurological disease, distinct from chronic fatigue as a symptom.
Icon based on the Lemmy logo by Andy Cuccaro licensed under the Creative Commons Attribution-Share Alike 4.0 International license. Eyes taken from the r/cfs logo.
!cfs
@feddit.dehttps://www.mdpi.com/1422-0067/25/8/4522
Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients suffering from persistent symptoms (post-acute sequelae) after serologically confirmed SARS-CoV-2 infection (post-COVID-19 syndrome, PCS, n = 8) or following SARS-CoV-2 vaccination (PVS, n = 8) were included. Asymptomatic subjects with corresponding serological findings served as healthy controls (n = 8/8). HDL was isolated using dextran sulfate precipitation and the HDL proteome of all study participants was analyzed quantitatively by mass spectrometry. Clinical symptoms were assessed using questionnaires before and after therapy. The inflammatory potential of the patients’ HDL proteome was addressed in human endothelial cells. The HDL proteome of patients with PCS and PVS showed no significant differences; however, compared to controls, the HDL from PVS/PCS patients displayed significant alterations involving hemoglobin, cytoskeletal proteins (MYL6, TLN1, PARVB, TPM4, FLNA), and amyloid precursor protein. Gene Ontology Biological Process (GOBP) enrichment analysis identified hemostasis, peptidase, and lipoprotein regulation pathways to be involved. Treatment of PVS/PCS patients with statins plus ARBs improved the patients’ clinical symptoms. After therapy, three proteins were significantly increased (FAM3C, AT6AP2, ADAM10; FDR < 0.05) in the HDL proteome from patients with PVS/PCS. Exposure of human endothelial cells with the HDL proteome from treated PVS/PCS patients revealed reduced inflammatory cytokine and adhesion molecule expression. Thus, HDL proteome analysis from PVS/PCS patients enables a deeper insight into the underlying disease mechanisms, pointing to significant involvement in metabolic and signaling disturbances. Treatment with statins plus ARBs improved clinical symptoms and reduced the inflammatory potential of the HDL proteome. These observations may guide future therapeutic strategies for PVS/PCS patients.
https://www.s4me.info/threads/news-in-brief-may-2024.38393/#post-533010/
This thread has a Science for ME 'News in Brief' post for each week in May 2024 by a team including @Trish, @Kalliope, @ahimsa and @SNT Gatchaman....
https://m.youtube.com/watch?v=VImABXhAP8A&feature=youtu.be
We have been given the green light for our new scan tracking leukocyte infiltration of the brain. We can now run the first-ever patient! I wanted to share th...
https://www.thecanary.co/opinion/2024/04/08/me-cfs-millie-nhs/
Nearly 20 years after the NHS killed Sophia Mirza, people with ME/CFS are still dying. Why? Why has nothing the ME community done worked?
https://news.griffith.edu.au/2024/03/15/health-outcomes-for-long-covid-are-comparable-with-me-cfs/
People with Long COVID in Australia have poor health outcomes that are comparable with another emerging disease known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).