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I get this message whenever I try to start a new game in skyrim. How do i fix the issue?

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Did you try making sure Sacrosanct is loaded below other mods that modify PlayerVampireQuestScript and/or DLC1PlayerVampireChangeScript and making sure there aren’t any loose copies of the scripts in your data/scripts folder? Sounds like conflicting mods

Rasm635u

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Sancrosanct is no. 397/400 in my load order. The remaining three plugins are patches for Sacrosanct

GARlactic

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I think your problem is that you have four hundred mods installed.

Rasm635u

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I use Vortex so most of them of the plugins are light

RedCat

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Have you tried changing the load order of your mods? Might be as simple as that.

Maybe you need to rebuild your merged patch and/or bashed patch.