Alcohol, Nicotine, Caffeine, Cannabis, LSD, Ketamine, MDMA, 2C-B, 4-MMC, Kratom, Psilocybin, Muscimol, Cocaine, ODSMT (tramadol), Amphetamine.
Alcohol I consider the most dangerous and destructive of all. It is very hard on my body and tolerance as well as dependence build up quickly and often noticed too late due to social acceptance.
MDMA is great taken responsibly with loved ones. My wife and I enjoy it every few months for a “free parents weekend”. It really helps opening up emotionally and makes physical touch even more enjoyable.
My almost daily vice is weed. I use it to manage stress and unwind after work. It works best when I do it together with exercise. The workout high is my personal favourite.
Shrooms are also great. They are easy to grow and very pleasant to me. After I’ve done a high dose (6g) I can do 2-3g as a chill daytime dose that mellows me out. It’s especially great for playtime with children - brings me kind of to the same mental level without losing my mental capacity.