https://arstechnica.com/health/2023/11/crispr-gene-editing-shown-to-permanently-lower-high-cholesterol/
Folks with hereditary high cholesterol would be able avoid lifelong medication.
!science
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I'd love to see the health outcomes of this sort of approach in general. One thing that has always irked me though is that we don't directly test for cholesterol, we test for the expression of cholesterol carrier protein, and as far I know, don't distinguish Apo versus Holo. Just presuming that expression scales linearly with cholesterol levels with no deviations for genetics (among other factors) just feels like an enormous leap of faith.